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| GRANISETRON HYDROCHLORIDE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. |
109889-09-0
; 121061-98-1 (Base) |
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| EINECS NO. | ||
| FORMULA | C18H24N4O·HCl | |
| MOL WT. | 348.87 | |
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H.S. CODE |
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TOXICITY |
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| SYNONYMS | Kytril; | |
| 1-Methyl-N-(endo-9-methyl-9-azabicyclo[3.3.1]non-3-yl)-1H-indazole- 3-carboxamide Monohydrochloride; Monoclorhidrato de 1-Metil-N-(9-metil-endo-9-azabiciclo [3.3.1]non-3- il-1-H-indazol-3-carboxamida; endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H- indazole-3-carboxamide hydrochloride; | ||
CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE | White to off-white Crystals | |
| MELTING POINT | ||
| BOILING POINT | ||
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | ||
| pH | 4.7 - 7.3 | |
| VAPOR DENSITY |
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| AUTOIGNITION |
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| NFPA RATINGS | Health: 1 Flammability: 1 Reactivity: 0 | |
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REFRACTIVE INDEX |
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| FLASH POINT | ||
| STABILITY |
Stable under ordinary conditions |
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APPLICATIONS |
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| Granisetron is an antiemetic agent to prevent the nausea and vomiting in conjunction with cancer chemotherapy or with radiation therapy, by blocking 5-HT3 receptors without effect on other receptors such as dopamine D2 receptor and 5-HT4 receptor. The hydrochloride salt of granisetron is a white to off-white crystalline powder; soluble in water and saline; administered intravenously. Chemical designation is endo-N-(9-methyl-9- azabicyclo [3.3.1] non-3-yl)-1-methyl-1H- indazole-3-carboxamide hydrochloride. Ondansetron is another 5-HT3 receptors antagonist used as an antiemetic or antinauseant. The chemical designation is 2,3-dihydro (or 1,2,3,9-tetrahydro)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl]- 4H-carbazol-4-one. The medicinal actions of granisetron and ondansetron are almost same. Alosetron, 2,3,4,5-tetrahydro-5- methyl- 2-[ (5-methyl-1H- imidazol-4-yl) methyl]-1H-pyrido[4,3-b] indol-1-one, is an 5-HT3 receptor also, but it is used in the treatment of diarrhea-predominant (IBS-D). | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
White to off-white Crystals | |
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IDENTITY |
passes test |
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| PURITY |
99.0% min |
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| pH |
4 - 6 |
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HEAVY METALS |
20ppm max |
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| LOSS ON DRYING |
0.5%
max
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| TRANSPORTATION | ||
| PACKING |
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| HAZARD CLASS | ||
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